Affinity Publisher 1.10.4

The 1.10.3 desktop release builds have now been replaced with 1.10.4 release builds to fix a few issues that have come to light shortly after release. This announcement post has been repurposed to include these minor changes. On the Affinity Store 1.10.4 should be available now (from your account and the link in each announcement, and on auto-update very soon). 1.10.4 builds will be rolling out on the Mac App Store and Microsoft store over the next 24-48 hours as normal.

Affinity Publisher 1.10.4

Download Affinity Designer 1.10.4 free latest full version complete standalone offline DMG setup for macOS. Affinity Designer is a professional-grade photo editing and design application that offers the latest tools to retouch your photos and improve their appearance and quality.

Since this opens near flawlessly in Affinity Publisher, looks like the default answer of blaming Microsoft is no longer valid, as some have noted. Your mileage may vary but this workflow works for me on macOS 12.3, Affinity Publisher 1.10.4, both on Apple silicon.

It is currently unknown how differences in the mutation profiles of BA.4 and BA.5, relative to BA.2, will affect their phenotypes. Changes at spike amino acids 452, 486 and 493 are likely to influence human angiotensin-converting enzyme-2 (hACE2) and antibody binding. The 452 residue is in immediate proximity to the interaction interface of the hACE2 receptor. The L452R mutation has been associated with an increased affinity for receptor binding with a resultant increased in vitro infectivity8. The L452R mutation is also present in the Delta, Kappa and Epsilon variants (and L452Q in Lambda), and mutations at this position have been associated with a reduction in neutralization by monoclonal antibodies (particularly class 2 antibodies) and polyclonal sera9,10,11. Mutations at this position (L452R/M/Q) have also arisen independently in several BA.2 sublineages in different parts of the world, most notably BA.2.12.1 (L452Q), which has become dominant in many parts of the United States. It is, therefore, unclear whether BA.4/BA.5 will become dominant throughout the world or whether there will be a period of co-circulation of several different Omicron lineages. 041b061a72